Influence of antigenic experience on BJ gene segment usage in human CD4+ T cells
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چکیده
منابع مشابه
Antigenic experience dictates functional role of glycogen synthase kinase-3 in human CD4+ T cell responses.
Signals induced by the TCR and CD28 costimulatory pathway have been shown to lead to the inactivation of the constitutively active enzyme, glycogen synthase kinase-3 (GSK3), which has been implicated in the regulation of IL-2 and T cell proliferation. However, it is unknown whether GSK3 plays a similar role in naive and memory CD4(+) T cell responses. Here we demonstrate a divergence in the dep...
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Human CMV infection is controlled by T cell-mediated immunity and in immunosuppressed transplant patients it is associated with acute allograft rejection as well as chronic allograft vasculopathy. CMV infects endothelial cells (EC) and it is thought that CMV-specific host immune responses to infected allograft EC contribute to rejection. In vitro, CD4(+) T cells from CMV-positive donors (but no...
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ژورنال
عنوان ژورنال: International Immunology
سال: 1997
ISSN: 1460-2377
DOI: 10.1093/intimm/9.12.1785